Status:
COMPLETED
Circadian Rhythmicity in Cold-induced Thermogenesis
Lead Sponsor:
Leiden University Medical Center
Conditions:
Healthy
Obese
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
This study aims to investigate whether maximum cold-induced non-shivering thermogenesis (e.g. thermogenesis as a consequence of BAT activity) differs between morning and evening.
Detailed Description
Brown adipose tissue (BAT) recently emerged as a novel player in energy expenditure (EE) in humans as it combusts fatty acids and glucose towards heat. Human BAT can be activated by sympathetic stimul...
Eligibility Criteria
Inclusion
- Dutch white Caucasian males or females
- Age: 18-35 years
- Lean group: BMI ≥ 18 and ≤ 25 kg/m2
- Obese glucose tolerant group: BMI ≥ 30 and ≤ 42 kg/m2 and fasted plasma glucose levels \< 5.5 and/or 2 h after OGTT ≤ 7.8 mM
- Obese impaired glucose tolerant group: BMI ≥ 30 and ≤ 42 kg/m2 and fasted plasma glucose levels ≥ 5.5 and/or 2 h after OGTT between 7.8 and 11.1 mM
Exclusion
- Diabetes mellitus (determined on basis of fasting or OGTT defined by ADA criteria (30)
- Any other active endocrine disease (thyroid disease, any signs of Cushing's syndrome, adrenal disease and lipid-associated disorders such as familial hypercholesterolemia)
- Any chronic renal or hepatic disease
- Use of medication known to influence glucose and/or lipid metabolism or brown fat activity (e.g. beta blockers, antidepressants)
- Smoking
- Abuse of alcohol or other substances
- Pregnancy
- Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
- Current participation in another research projects that may influence the current research project
- Clinically relevant abnormalities in clinical chemistry at screening (to be judged by the study physician)
Key Trial Info
Start Date :
April 23 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2021
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04406922
Start Date
April 23 2019
End Date
January 1 2021
Last Update
April 19 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Leiden University Medical Center
Leiden, Netherlands, 2333ZA