Status:
COMPLETED
Efficacy and Safety of Ivermectin and Doxycycline in Combination or IVE Alone in Patients With COVID-19 Infection.
Lead Sponsor:
International Centre for Diarrhoeal Disease Research, Bangladesh
Conditions:
COVID-19 Patients
Eligibility:
All Genders
40-65 years
Phase:
PHASE2
Brief Summary
Burden: Initial outbreak of corona virus disease 2019 (COVID-19) was reported from Wuhan, China in early December 2019.Presently known to be caused by a novel beta-corona virus, named as Severe acute...
Detailed Description
Objectives: General Objective: The aim of the study is to evaluate efficacy and safety of ivermectin in combination with doxycycline or ivermectin alone for the treatment of hospitalized SARS-CoV-2 ...
Eligibility Criteria
Inclusion
- Inclusion criterion:
- Bangladeshi aged 18-65 years admitted to any of the aforementioned study sites (hospitals)
- Either sex
- At the enrollment having at least one of the following symptoms: Temp 37.5 C or above, Cough, Sore throat
- SpO2 \>94%
- Duration of illness ≤ 7 days
- No oxygen support on enrollment
- Capable of swallowing oral medication
- PCR positive for SARS-CoV2 virus
- The participant properly informed about the study and agreed to sign the informed consent form (ICF)
- Exclusion Criteria:
- Allergy to ivermectin or doxycycline; or other contraindications to any of the study medications
- History of chronic heart disease (IHD, heart failure, documented cardiomyopathy etc)
- History of chronic liver disease (SGPT value more than 3 times of normal value)
- History of chronic kidney disease (S. Creatinine for male \>1.3 mg/dL or \>115 µmol/L and for female \>1.2 mg/dL or \>106.1 µmol/L)
- Pregnant or lactating women
- Participated in any other clinical trial within last 4 weeks
- H/o received Ivermectin/Doxycycline within last 7 days
Exclusion
Key Trial Info
Start Date :
June 16 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 20 2020
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT04407130
Start Date
June 16 2020
End Date
November 20 2020
Last Update
February 4 2021
Active Locations (1)
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1
Icddr,B
Dhaka, Bangladesh, 1000