Status:
COMPLETED
Statin Therapy and COVID-19 Infection
Lead Sponsor:
Institut Investigacio Sanitaria Pere Virgili
Conditions:
COVID
Statin
Eligibility:
All Genders
18+ years
Brief Summary
Considering that simvastatin, and probably statins in general, interfere with SARS-cov-2 cellular uptake and some inflammatory pathways activated by the virus, those patients on statin therapy should ...
Detailed Description
Statins reduce intracellular cholesterol synthesis by interfering with the limiting enzyme HMGCoA reductase. A lower intracellular cholesterol concentration leads to activation of the transcription fa...
Eligibility Criteria
Inclusion
- Patients ≥ 18 years old with a PCR or immunological confirmation of Covid-19 infection, admitted in the hospital for at least 24 hours, will be included.
Exclusion
- Patients \< 18 years old.
Key Trial Info
Start Date :
May 14 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2020
Estimated Enrollment :
2159 Patients enrolled
Trial Details
Trial ID
NCT04407273
Start Date
May 14 2020
End Date
December 30 2020
Last Update
March 11 2021
Active Locations (1)
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1
Facultat de Medicina i Ciències de la Salut de Reus
Reus, Tarragona, Spain, 43201