Status:
COMPLETED
Anti-Obesity Phentermine-Topiramate Extended Release Pharmacotherapy vs Placebo Among Patients Using a Wearable Activity Tracker
Lead Sponsor:
Mayo Clinic
Conditions:
Obesity
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
Researchers are assessing the effects of weight loss medication vs a placebo among participants provided with a wearable activity tracker, digital wellness devices and lifestyle recommendations.
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Adults with obesity (BMI \>30Kg/m2); these will be otherwise healthy individuals with no unstable psychiatric disease and controlled comorbidities or other diseases.
- Age: 18-75 years.
- Gender: Men or women. Women of childbearing potential will have negative pregnancy tests within 48 hours of enrollment.
- Women of childbearing potential must agree to use a method of effective contraception during study participation.
- Subject must have an Apple iPhone 6s or later with iOS 13 or later and be willing to download the VitalCare (VitalTech Affiliates LLC) application from the Apple App Store.
- Able to provide written informed consent prior to any study procedures, and be willing and able to comply with study procedures
- Exclusion Criteria
- History of Abdominal bariatric surgery
- Weight is greater than 450 lbs (204 kg)
- Recent use (within the last three months) of any antiobesity medication
- Recent weight change (gain or loss weight greater than 3% TBW in the last 3 months)
- Positive history of chronic gastrointestinal diseases, or systemic disease that could affect gastrointestinal motility, or use of medications that may alter gastrointestinal motility, appetite or absorption, e.g., orlistat, within the last 6 months.
- Significant untreated psychiatric dysfunction based upon screening with the Hospital Anxiety and Depression Inventory (HAD), and the Questionnaire on Eating and Weight Patterns (binge eating disorders and bulimia). If such a dysfunction is identified by an anxiety or depression score \>11 or difficulties with substance or eating disorders, the participant will be excluded and given a referral letter to his/her primary care doctor for further appraisal and follow-up.
- Hypersensitivity or contraindication to the study medication.
- Participant unable or unwilling to follow protocol including use of the wearable activity tracker, digital wellness devices, VitalCare application, or unwilling to sign consent.
- Principal Investigator discretion
Exclusion
Key Trial Info
Start Date :
June 3 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 11 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04408586
Start Date
June 3 2020
End Date
October 11 2022
Last Update
June 22 2023
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905