Status:
COMPLETED
A Study of LY3819253 (LY-CoV555) in Participants Hospitalized for COVID-19
Lead Sponsor:
Eli Lilly and Company
Collaborating Sponsors:
AbCellera Biologics Inc.
Conditions:
COVID-19
Eligibility:
All Genders
18-75 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to test the safety and tolerability of LY3819253 when it is given by injection into a vein to participants hospitalized with COVID-19. Blood tests will be done to check ho...
Eligibility Criteria
Inclusion
- Are hospitalized or in the process of being admitted to hospital and have an initial laboratory determination of current COVID-19 infection less than or equal to (≤)72 hours prior to randomization
- Are men or non-pregnant women
- Women of childbearing potential must agree to use at least one highly effective form of contraception for the entirety of the study
- Agree to the collection of nasopharyngeal swabs and venous blood
Exclusion
- Require mechanical ventilation or anticipated impending need for mechanical ventilation
- Received convalescent COVID-19 plasma treatment prior to enrollment
- Were resident in a nursing home or long-term care facility immediately prior to current hospitalization
- Suspected or proven serious, active bacterial, fungal, viral, or other infection (besides COVID-19) that in the opinion of the investigator could constitute a risk when taking investigational product
- Have an oxygen saturation (SpO2) less than (\<)88 percent (%) while breathing room air at rest at randomization.
Key Trial Info
Start Date :
May 28 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 26 2020
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04411628
Start Date
May 28 2020
End Date
August 26 2020
Last Update
November 12 2021
Active Locations (11)
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1
Cedars Sinai Medical Center
Los Angeles, California, United States, 90048
2
Veterans Affairs Medical Center San Diego
San Diego, California, United States, 92161
3
Emory University
Atlanta, Georgia, United States, 30322
4
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114