Status:
RECRUITING
Inflammatory faCtors AfteR acUte Ischemic Stroke
Lead Sponsor:
Martin Dichgans
Collaborating Sponsors:
Universitätsklinikum Hamburg-Eppendorf
University Hospital Muenster
Conditions:
Ischemic Stroke
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
ICARUS is an interventional single-centre hospital-based cohort study in patients admitted to the stroke unit with an acute ischemic stroke. The aims of the study are to i) define the characteristics ...
Detailed Description
The neuroinflammatory response after ischemic brain injury has been identified as a pathomechanism in ischemic stroke. Stroke induces an activation of microglia in the brain, which lasts over months. ...
Eligibility Criteria
Inclusion
- Age ≥ 50 years
- Acute ischemic stroke (time frame: \<72 hours) as defined by an acute focal neurological deficit in combination with a corresponding infarct as documented by a diffusion weighted imaging (DWI)-positive lesion on magnetic resonance imaging (MRI); presence of an infarct involving the cortex or a strictly subcortical infarct
- Written informed consent prior to study participation
- Willingness to participate in study assessments including follow-up
Exclusion
- Unwillingness or inability to give written consent
- Prior history of stroke, multiple infarcts, infratentorial infarcts affecting the brain stem or cerebellum
- Known diseases of the CNS other than stroke
- Immunomodulatory therapies within the last 3 months prior stroke
- Chronic inflammatory disease
- Infectious diseases within the last 7 days prior stroke
- Conditions interfering with follow-up such as end-stage malignancy
- Contraindications for MRI or PET (pacemaker, aneurysm clip, cochlear implant etc.)
- Radiation exposure of \> 10mSv per year
- Pregnant or breastfeeding women
- Participation in a clinical trial
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04412187
Start Date
July 1 2020
End Date
December 31 2027
Last Update
April 4 2025
Active Locations (2)
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1
Insitute for Stroke and Dementia Research
Munich, Germany, Germany, 81377
2
Department of Nuclear Medicine
Munich, Germany, 81377