Status:
COMPLETED
MiRNA in Kidney Transplantation: Association With Kidney Graft Function and Disease Process
Lead Sponsor:
University Medical Centre Ljubljana
Conditions:
Kidney Transplant Failure and Rejection
Eligibility:
All Genders
18+ years
Brief Summary
MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that modulate physiological and pathological processes by post-transcriptional regulation of gene expression mainly via translational inhi...
Detailed Description
MicroRNAs (miRNA) are short, endogenous non-coding RNAs involved in the modulation of gene expression mainly by inhibition of messenger RNAs translation. Recent studies have indicated association of m...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- time of kidney transplantation at least 2 years before the study entry,
- stable function of the transplanted kidney during the previous 3 months (changes in s-creatinine ≤ 20%).
- Exclusion criteria:
- age less than 18 years,
- symptomatic heart failure,
- malignancy,
- pregnancy or lactation,
- acute conditions and diseases that can affect the GFR,
- newly-introduced drugs that may affect the function of the graft,
- treatment with trimethoprim-sulfamethoxazole or cimetidine,
- the presence of a pacemaker or any other electronic device in the body.
Exclusion
Key Trial Info
Start Date :
January 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04413916
Start Date
January 1 2019
End Date
December 31 2019
Last Update
June 4 2020
Active Locations (1)
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1
University Medical Centre Ljubljana
Ljubljana, Slovenia, 1000