Status:
COMPLETED
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A
Lead Sponsor:
ShangHai Ji Ai Genetics & IVF Institute
Conditions:
Preimplantation Genetic Testing
Progestin-primed Ovarian Stimulation
Eligibility:
FEMALE
20-43 years
Phase:
PHASE3
Brief Summary
This randomized trial aims to compare the euploid rate of blastocysts between PPOS and GnRH antagonist protocols in patients undergoing PGT-A. Infertile women who have medical indication for PGT-A wil...
Eligibility Criteria
Inclusion
- Age of women \<43 years at the time of ovarian stimulation for IVF
- Antral follicle count (AFC) \>=5 on day 2-5 of the period
- PGT-A indicated for advanced maternal age (\>=38 years), recurrent miscarriage (\>=2 consecutive miscarriage) and repeated implantation failure (\>=4 embryos replaced or \>=2 blastocysts replaced without success), recurrent foetal aneuploidy
Exclusion
- Presence of a functional ovarian cyst with E2\>100 pg/mL
- Recipient of oocyte donation
- Presence of hydrosalpinx or endometrial polyp which is not surgically treated
Key Trial Info
Start Date :
June 10 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 27 2025
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04414748
Start Date
June 10 2020
End Date
May 27 2025
Last Update
May 31 2025
Active Locations (1)
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1
Shanghai JiAi Genetics & IVF Institute
Shanghai, Shanghai Municipality, China, 200011