Status:
COMPLETED
Low-dose S-ketamine in Women With Prenatal Depression
Lead Sponsor:
Peking University First Hospital
Collaborating Sponsors:
Peking University International Hospital
Hunan Provincial Maternal and Child Health Care Hospital
Conditions:
Prenatal Depression
Ketamine
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ket...
Detailed Description
Studies have shown that prenatal depression symptoms are important predictors of postpartum depression. Screening of pregnant women's mental condition before giving birth, early identification of preg...
Eligibility Criteria
Inclusion
- Maternal age ≥18 years;
- Prenatal Edinburgh postnatal depression scale score ≥10 points.
Exclusion
- A clear history of mental illness (depression, schizophrenia, etc.) or communication difficulties;
- Severe pregnancy complications, such as severe preeclampsia, placental implantation, HELLP (syndrome hemolytic anemia, elevated liver function and low platelet count) syndrom, placenta previa, and placental abruption;
- American Society of Anesthesiologists classification ≥III;
- Presence of contraindications to ketamine/s-ketamine use, such as refractory hypertension, severe cardiovascular disease (New York Heart Association classification ≥III), and hyperthyroidism.
Key Trial Info
Start Date :
June 19 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 3 2022
Estimated Enrollment :
364 Patients enrolled
Trial Details
Trial ID
NCT04414943
Start Date
June 19 2020
End Date
August 3 2022
Last Update
April 4 2023
Active Locations (7)
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1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
2
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China
3
Peking University International Hospital
Beijing, Beijing Municipality, China
4
Hunan Provincial Maternal and Child Health Care Hospital
Changsha, Hunan, China