Status:
COMPLETED
Effect of Paracetamol and Ibuprofen Reducing Morphine Requirements After Total Knee Arthroplasty
Lead Sponsor:
Indonesia University
Conditions:
Analgesia
Eligibility:
All Genders
50-75 years
Phase:
PHASE2
PHASE3
Brief Summary
Adequate pain management has an important role in supporting early ambulation after the Total Knee Arthroplasty (TKA). Multimodal analgesia is one of the modalities of overcoming postoperative pain. T...
Detailed Description
The research will compare the effect of paracetamol injection and ibuprofen injection when given alone or in combination to reduce morphine requirement in a patient after total knee arthroplasty
Eligibility Criteria
Inclusion
- Adult patient with 20 \< BMI \< 30 kg/m2
- Adult patient with knee varus alignment 10-20°
Exclusion
- Impaired cardiac, liver, and/or renal function.
- History of substance abuse or chronic pain.
- Patients are known to be hypersensitive to any of the components of IV ibuprofen or IV paracetamol.
- Patients currently on anticoagulation medications.
- Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by an Institutional Review Board) and agree to abide by the study restrictions.
Key Trial Info
Start Date :
June 5 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 15 2020
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04414995
Start Date
June 5 2020
End Date
December 15 2020
Last Update
December 22 2020
Active Locations (2)
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1
Fatmawati General Hospital
Jakarta, DKI Jakarta, Indonesia, 12430
2
Cipto Mangunkusumo National General Hospital
Jakarta Pusat, DKI Jakarta, Indonesia, 10430