Status:
ENROLLING_BY_INVITATION
Macromolecular Imaging of White and Gray Matter Pathology in Multiple Sclerosis
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Conditions:
Multiple Sclerosis
MS
Eligibility:
All Genders
18-60 years
Brief Summary
The overall purpose of this research is to determine whether new macromolecular measures optimized for whole brain (gray matter and white matter) magnetic resonance imaging (MRI), predict neuro-cognit...
Detailed Description
MRI is a vital component of a MS work-up, providing noninvasive evidence of MS lesions, detecting active inflammatory lesions, and measuring brain atrophy to assess neurodegeneration. Recent years of ...
Eligibility Criteria
Inclusion
- Clinically definite MS
- Adult age 18 to 60
Exclusion
- Contraindication to MRI
- Changes in MS therapy in the last 6 months
- Less than 6 weeks after relapse or corticosteroid use
- Currently taking medication that may affect cognition (e.g. donepezil, rivastigmine, adderall)
- History of significant alcohol or drug abuse
- Current or recent significant migraines
- Confounding neurological or cognitive disorders or deficits (stroke, Parkinson's disease, Alzheimer's disease, epilepsy)
- Sensory or physical impairments that might interfere significantly with cognitive testing
- History of developmental or learning disability or attention-deficit/hyperactivity disorder.\\
- Exclusion Criteria for Healthy Controls:
- history of alcohol/drug abuse
- history of migraines
- developmental or learning disability/attention-deficit/hyperactivity disorder
- currently pregnant/breastfeeding
Key Trial Info
Start Date :
November 19 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2027
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT04415372
Start Date
November 19 2021
End Date
April 1 2027
Last Update
April 22 2025
Active Locations (1)
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1
University of Wisconsin, Madison
Madison, Wisconsin, United States, 53705