Status:
UNKNOWN
Changes in Metabolic Activity, and Gait Function by Dual-task Cognitive Game-based Treadmill Intervention in Parkinson's Disease.
Lead Sponsor:
University of Manitoba
Collaborating Sponsors:
Weston Brain Institute
Conditions:
Parkinson Disease
Eligibility:
All Genders
55-70 years
Phase:
NA
Brief Summary
The present proposal will evaluate the neural underpinnings of (a) the decline of mobility function in Parkinson's disease (PD), and (b) the effects of an innovative computer-guided dual-task (DT) mob...
Detailed Description
The present proposal will evaluate the neural underpinnings of (a) the decline of mobility function in Parkinson's disease (PD), and (b) the effects of an innovative computer-guided dual-task (DT) mob...
Eligibility Criteria
Inclusion
- (PD Participants)
- Diagnosed with idiopathic PD, defined by the UK Brain Bank criterion in disease stage 2 - 3 (classified by Hoehn and Yahr scale),
- Montreal cognitive assessment (MoCA) scores to be 25 or higher
- Age 55-70 years
- Stable medications for Parkinson over the past 3 months
- Able to walk at least 50m without any assistive device
- Episode of FOG in the past 6 months
Exclusion
- (PD Participants)
- The presence of neurological conditions other than PD affecting cognitive abilities.
- Any orthopedic impairment affecting gait and balance.
- Any cardiovascular impairment limiting the ability to walk for 10-15 minutes on a treadmill;
- Abnormal MRI
- General contraindications.
- Inclusion Criteria: (Healthy Controls)
- Age 55-70 years,
- Independent community living,
- Not receiving any home care or Physiotherapy,
- Walking outdoors for exercise for at least 3 times per week,
- No neurological conditions affecting mobility or affecting cognitive abilities,
- Any orthopedic impairment affecting gait and balance.
- Any cardiovascular impairment limiting the ability to walk for 10-15 minutes on a treadmill.
- Abnormal MRI and
- General contraindications for PET and MRI including severe dyskinesia, diabetes, cardiac pacemakers.
- Exclusion Criteria (Healthy Controls):
- Any orthopedic impairment affecting gait and balance.
- Any cardiovascular impairment limiting the ability to walk for 10-15 minutes on a treadmill.
- Abnormal MRI
- General contraindications.
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2023
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT04415775
Start Date
June 1 2021
End Date
November 1 2023
Last Update
May 11 2021
Active Locations (1)
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1
College of Rehabilitation Sciences, University of Manitoba
Winnipeg, Manitoba, Canada, R3E 0T6