Status:
COMPLETED
Hormonal and Inflammatory Biomarkers and Response to Cognitive Remediation in Recent-onset Psychosis
Lead Sponsor:
Corporacion Parc Tauli
Collaborating Sponsors:
Instituto de Salud Carlos III
Conditions:
Psychotic Disorders
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This study aims to explore whether hormones or inflammatory markers are associated with cognitive changes following cognitive remediation therapy (CRT) in people with a recent-onset psychotic disorder...
Detailed Description
Cognitive dysfunction is a core feature of schizophrenia experienced by approximately 75% of the patients. It may occur at the early stages of psychosis, and it is usually unaltered despite positive s...
Eligibility Criteria
Inclusion
- Psychotic disorder meeting Diagnostic and Statistical Manual of Mental Disorders - 4th edition (DSM-IV) criteria for any of the following diagnoses: schizophrenia, schizoaffective disorder, bipolar disorder, and psychotic disorder not otherwise specified.
- Recent-onset psychosis (\< 3 years of illness).
- Outpatients with stable illness (\<4 points in each positive item of the Positive and Negative Syndrome Scale \[PANSS\]).
- Being on community treatment for at least 4 weeks.
Exclusion
- Refusal to participate.
- Severe neurological disease or intellectual disability.
- Pregnancy.
- Substance-induced psychosis.
- History of severe traumatic brain injury.
- Current treatment with glucocorticoids.
- Visual deficits or language difficulties that could influence cognitive assessment and intervention.
Key Trial Info
Start Date :
July 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2020
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT04418570
Start Date
July 1 2016
End Date
March 1 2020
Last Update
June 9 2020
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