Status:
COMPLETED
Characterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function
Lead Sponsor:
Yale University
Conditions:
Pain Response, Stress, Trauma
Eligibility:
All Genders
18-50 years
Brief Summary
The study design is to assess the between groups factor (controls, chronic pain, addicted individuals) and repeated measures factor of pain/stress (pain vs no pain) along with a longitudinal component...
Detailed Description
This proposal aims to systematically examine the physiologic, neuroendocrine and behavioral stress and pain responses to an adapted Cold Pressor Test and also assess specific cognitive and executive f...
Eligibility Criteria
Inclusion
- Between ages 18-50 years;
- Able to read and write English;
- 50 individuals meeting DSM V criteria for Binge Heavy drinkers, using NIAAA criteria for alcohol intake 50 individuals meeting DSM V criteria for Cannabis Use Disorder 50 individuals meeting DSM V criteria for Alcohol Use Disorder 50 Individuals with Moderate to Severe Pain 50 individuals meeting DSM V criteria for Opioid Use Disorder who are initiating treatment
- Physically healthy as determined by Physical Exam, EKG and blood analyses
- Body Mass Index (BMI) in the 18-30 range;
Exclusion
- Any psychotic disorder or current psychiatric symptoms requiring specific attention, including active symptoms of psychosis or suicidal/homicidal ideation.
- Any Current Substance Use Disorder including alcohol, cannabis, cocaine, opioids, sedatives/hypnotics. For alcohol, cannabis, and opioid subjects, exclusion for the abused drug will not apply.
- Individuals taking any prescription medications or over-the counter medications regularly;
- Women with irregular menstrual cycles or who are nursing, dysmennorheic, amenorrheic, menopausal, or had premenstrual dysphoric disorder or those on birth control pills;
- Women who are pregnant as determined by the urine pregnancy test at each laboratory admission;
- Inability to give informed consent;
- Traumatic brain injury or loss of consciousness;
- Individuals with current or past history of seizure disorders
Key Trial Info
Start Date :
April 14 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2023
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT04419831
Start Date
April 14 2022
End Date
December 30 2023
Last Update
February 7 2024
Active Locations (1)
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1
Yale Stress Center
New Haven, Connecticut, United States, 06519