Status:
TERMINATED
Desmopressin for Bedwetting in Children With SCD
Lead Sponsor:
Montefiore Medical Center
Conditions:
Nocturnal Enuresis
Anemia, Sickle Cell
Eligibility:
All Genders
8-21 years
Phase:
PHASE4
Brief Summary
This study assesses if using the medication desmopressin will decrease nightime bedwetting in children with sickle cell disease.
Detailed Description
Night time bedwetting is a common complication of sickle cell disease, and affects up to 30 % of children. Desmopressin is an oral medication that increases water reabsorption in the kidneys. Studies ...
Eligibility Criteria
Inclusion
- Patients with Hemoglobin SS, SC, SB0thal or SB+thal
- Patients with at least two episodes of primary nocturnal enuresis per week or four episodes over the two weeks prior to enrollment.
- Patients with secondary enuresis who have been evaluated and cleared by a pediatric urologist as not having other etiologies of enuresis (e.g. overactive detrusor activity, a genitourinary anatomic abnormality)
Exclusion
- Patients with developmental delay or neurologic dysfunction secondary to stroke.
- Patients with hypertension or underlying renal disease.
- Patients with genitourinary anatomic abnormalities. Any prior renal ultrasound showing normal genitourinary anatomy is sufficient to clear a patient for the study.
- Patients with daytime urinary incontinence
- Patients with glucosuria on urinalysis.
- Patients with secondary nocturnal enuresis who have not been evaluated by a pediatric urologist to rule out other etiologies of enuresis.
- Patients who are pregnant.
- Patients receiving another medicine for nocturnal enuresis (e.g. imipramine).
Key Trial Info
Start Date :
July 7 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 12 2023
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT04420585
Start Date
July 7 2020
End Date
June 12 2023
Last Update
May 7 2024
Active Locations (1)
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1
Children's Hospital at Montefiore
The Bronx, New York, United States, 10467