Status:
COMPLETED
Histological, Genetic and Epigenetic Analysis of Procedures Related with Dental Implants
Lead Sponsor:
Simón Pardiñas López
Collaborating Sponsors:
NYU Langone Health
Göteborg University
Conditions:
Peri-Implantitis
Peri-implant Mucositis
Eligibility:
All Genders
20-90 years
Brief Summary
In this study genomic, proteomic and histological technologies for the search and characterization of epigenetic modifications and molecular or protein markers, useful in the diagnosis and progression...
Detailed Description
Samples stored at the Biomedical Research Institute of A Coruña, Xerencia Integrated Management of A Coruña (University Hospital Center of A Coruña), belonging to the collection of the line of researc...
Eligibility Criteria
Inclusion
- The subjects must have read, understood and signed an informed consent regarding the obtaining of biological samples and participation in the research line of "Oral Health and Systemic Relationship" existing in the Pardiñas Dental Medical Clinic and approved by the ethical committee.
- The subjects must be between 20-90 years of age.
- Subjects must be non-smokers or former smokers who have quit smoking for at least one year prior to enrollment in the study.
- In addition to the general criteria listed, samples of a healthy periodontal subject must meet the following criteria when reviewing their medical and dental history :
- Subjects do not have or have had a history of periodontal disease, as described in the " 2017 World Workshop on the Classification of Periodontal and Peri- Implant Diseases and Conditions "
- Samples from a subject with peri-implant disease must meet the following criteria:
- Samples of subjects who have at least one implant - supported prosthesis for at least 12 months and affected by peri- implant disease according to the " 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions "
Exclusion
- Samples of pregnant or lactating women at the time of collection.
- Samples of subjects who were taking antibiotics within 1 month before collection of the sample.
- Samples of subjects with chronic use of non-steroidal anti-inflammatory drugs for more than 3 weeks at the time of sample collection. The use of aspirin in low doses (≤81 mg / day) will be allowed .
- Samples from subjects with disease in the mucosa in the area located around the site of sample collection.
- Samples of subjects with a systemic disease that would exclude the analysis (for example, severe medical problems, bone metabolism disorders, uncontrolled bleeding disorders, depressed immune system, diseases that require the periodic use of steroids, uncontrolled endocrine disorders) .
- Samples of subjects with a history of local irradiation therapy in the head / neck area.
- Samples of subjects with a history of having received treatment with intravenous or subcutaneous antiresorptive agents associated with osteonecrosis of the jaw, such as bisphosphonates.
- Samples of subjects assigned to the healthy group that meet any of the following criteria will be excluded from participation in this study:
- Root fragments, pericoronaritis, endo-perio lesions, dental abscesses at the site of the biopsy.
- Presence of BOP in the sample collection site.
- Peri- implant disease samples / Exclusion of Subjects
- The samples of the subjects assigned to the peri- implant diseases group that meet any of the following criteria will be excluded from participation in this study if the implants were removed due to:
- Inadequate position of the implant.
- Subjects with implants previously treated surgically for peri- implant disease with antibiotics.
Key Trial Info
Start Date :
January 29 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 20 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04421066
Start Date
January 29 2019
End Date
June 20 2022
Last Update
February 26 2025
Active Locations (1)
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1
Fundacion Clinica Pardiñas
A Coruña, Galicia, Spain, 15003