Status:
COMPLETED
Biological Mechanisms in Afebrile P. Falciparum Malaria
Lead Sponsor:
Alfredo Mayor
Collaborating Sponsors:
Centro de Investigação em Saúde de Manhiça
Stanford University
Conditions:
Falciparum Malaria
Eligibility:
All Genders
18-60 years
Brief Summary
This project aims to disentangle the role of host immune resistance and disease tolerance in afebrile malaria infections, with the goal of guiding context-adapted tactics to target this hidden reservo...
Detailed Description
Asymptomatic Plasmodium falciparum (Pf) infections debilitate the health of affected population while representing a hidden source of parasite transmission that can compromise elimination efforts. The...
Eligibility Criteria
Inclusion
- Age ≥ 18 years and ≤60 years
- A positive RDT and microscopy for P. falciparum
- Axillary temperature \< 37.5ºC without history of fever during the last 24h
- No danger signals for severe malaria (Impaired consciousness, respiratory distress, multiple convulsions, prostration, shock, abnormal bleeding, jaundice)
- Ability and willingness to comply with the study protocol for the duration of the study and to comply with the study visit schedule; and
- Signed informed consent after explaining the purpose of the study
Exclusion
- Age \<18 years or \>60 years
- Axillary temperature ≥37.5ºC
- Reported pregnancy
- Presence of any sign/symptom of malaria (Vomiting, diarrhea, weakness, dizziness, fainting, itching, urticarial)
- Presence of any other co-existing clinical condition that would not allow the individual to be considered a "healthy" afebrile carrier
- Having received antimalarial medication in the preceding 30 days.
Key Trial Info
Start Date :
March 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2021
Estimated Enrollment :
475 Patients enrolled
Trial Details
Trial ID
NCT04422015
Start Date
March 1 2020
End Date
March 31 2021
Last Update
September 1 2023
Active Locations (1)
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1
Fundação Manhiça/Manhiça Health Research Center
Manhiça, Mozambique, 1929