Status:
UNKNOWN
Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction
Lead Sponsor:
RenJi Hospital
Collaborating Sponsors:
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
Tenth People's Hospital of Tongji Univeristy
Conditions:
Total Knee Arthroplasty
Fracture of Head of Femur Articular Displaced
Eligibility:
All Genders
60+ years
Phase:
PHASE4
Brief Summary
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy metho...
Eligibility Criteria
Inclusion
- Elder than 60 years old
- Speak Chinese Mandarin
- Scheduled to undergo hip or knee replacement surgery and lumbar spine surgery
- The operation time is more than 2 hours.
- Signed the informed consent
- American Society of Anesthesiologists (ASA) classification I-II
Exclusion
- Existing cerebral disease, or have a history of neurological and psychiatric diseases including Alzheimer Disease, stroke, epilepsy and psychosis
- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- Several audition or vision disorder
- Patients with tumors or infections
- Unwillingness to comply with the protocol or procedures
- Can not communicate normally in Mandarin Chinese
- Existing bradycardiac arrhythmia (Heart rate \<60 bpm for any reasons)
- Existing gastrointestinal ulcer
- Existing urinary incontinence
- Existing asthma or chronic obstructive pulmonary disease
- Postoperative admission to ICU
- Allergic to donepezil
Key Trial Info
Start Date :
June 14 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT04423276
Start Date
June 14 2020
End Date
December 1 2022
Last Update
December 29 2020
Active Locations (1)
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1
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127