Status:
WITHDRAWN
Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and Psoriasis
Lead Sponsor:
Germans Trias i Pujol Hospital
Conditions:
Psoriasis
Neuroinflammation
Eligibility:
All Genders
18-65 years
Brief Summary
Objectives: To identify peripheral neuroinflammatory markers in patients suffering from major depression or psoriasis in relation to affective symptoms (anxiety, depression, irritability), fatigue and...
Detailed Description
Design This is a prospective observational study of cohorts with patients diagnosed with major depression or psoriasis and subjected to different treatments with systemic or biological drugs in the ca...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age between 18 and 65
- Clinical diagnosis of:
- In the psoriasis group: diagnosis of plaque psoriasis made by a dermatologist, lasting at least 6 months.
- In the major depression group: clinical diagnosis of major depression according to DSM-5 criteria made by a psychiatrist.
- Patients receiving systemic or biological treatment for psoriasis, or antidepressant for major depression.
- Exclusion criteria:
- Previous treatments for psoriasis
- UVBBE phototherapy in the last 2 weeks
- PUVA phototherapy in the last 4 weeks
- Conventional systemic treatments in the last 4 weeks
- Biological treatments in the last 3 months
- Previous antidepressant treatments in the last 6 weeks
- Antipsychotic or eutimizing treatments in the last 6 weeks
- The presence of concurrent psychotic symptoms
- Alcohol or drug use disorders, with active consumption during the last 3 months
- Pregnant women
- Serious and / or unstable medical disorders, Addison or Cushing's disease, Rheumatoid arthritis or systemic lupus erythematosus.
Exclusion
Key Trial Info
Start Date :
February 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04423471
Start Date
February 1 2021
End Date
December 1 2022
Last Update
January 28 2022
Active Locations (1)
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1
Hospital Universitari Germans Trias i Pujol
Badalona, Catalonia, Spain, 08916