Status:
COMPLETED
Plasma Levels of Danger-Associated Molecular Patterns in Young Children After Cardiac Surgery Under Cardiopulmonary Bypass
Lead Sponsor:
Nantes University Hospital
Conditions:
Cardiac Surgical Procedure
Eligibility:
All Genders
Up to 3 years
Brief Summary
The investigators have previously reported that cardiac surgery with CPB ( cardiopulmonary bypass) in young infants induced a drastic reduction in mHLA-DR ( Human Leucocyte Antigen) expression, which ...
Detailed Description
Plasma levels of heat shock protein (HSP 70), high mobility group box (HMGB1), S100A9 and IL-33 will be measured at four time points (prior to the onset of CPB, Hour 6 postoperative, day 1 and day 3 a...
Eligibility Criteria
Inclusion
- Patient admitted to pediatric intensive care at Nantes University Hospital after cardiac surgery with bypass graft
- Age ≤ 3 months corrected age. Control group: patients less than 3 months old following cardiac surgery without CEC or digestive surgery with a central venous catheter.
Exclusion
- Futility of care with cessation of blood tests as part of a limitation of active therapies;
- Absence of parents for information
- Refusal of parents after information (Lack of parental consent)
- Blood volume collected for medical purposes incompatible with the needs of the research
Key Trial Info
Start Date :
September 2 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 2 2025
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT04423523
Start Date
September 2 2020
End Date
December 2 2025
Last Update
December 17 2025
Active Locations (1)
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1
Nantes University Hospital
Nantes, France, 44093