Status:
UNKNOWN
tDCS Intervention on Motivational Anhedonia of Major Depressive Disorder
Lead Sponsor:
Anhui Medical University
Conditions:
Transcranial Direct Current Stimulation
Major Depressive Disorder
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Study of tDCS intervention on motivational anhedonia of Major Depressive Disorder
Detailed Description
All patients underwent a medical evaluation that included physical examination and routine laboratory studies before and after transcranial direct current stimulation (tDCS) treatment. Patients were r...
Eligibility Criteria
Inclusion
- Meet criteria of depression assessed by at least two psychiatrists according to the five version of Diagnostic and Statistical Manual of Mental Disorders.
- The score of Hamilton Depression Rating Scale-17 was larger than 18.
- Patients were taking antidepressants--Selective Serotonin Reuptake Inhibitor(SSRIs) alone.
- Age was between 18 to 60 year old.
- The education duration was at least 6 years.
- The vision or corrected vision was normal.
- Right handedness.
- No treatment of rTMS, transcranial direct current stimulation or electroconvulsive therapy before.
Exclusion
- History of significant head trauma or neurological disorders.
- Alcohol or drug abuse.
- Focal brain lesions.
- History of seizure.
- First degree relative with epilepsy, significant neurological illness or head trauma, endocrine disease.
- Significant unstable medical condition.
- Recent aggression or other forms of behavioral dyscontrol.
- Left-handedness.
- Pregnancy.
- Current alcohol or drug abuse
- Inability to provide informed consent.
- Patients with contraindications or factors affecting imaging quality, such as pacemakers, cochlear implants, or hearts Cerebrovascular metal stent, and metal denture.
Key Trial Info
Start Date :
March 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04425278
Start Date
March 1 2018
End Date
December 31 2021
Last Update
June 11 2020
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230032