Status:
UNKNOWN
The Effect and Mechanism of lncRNA NBR2 Regulating Endothelial Pyroptosis by Targeting GSDMD in Sepsis
Lead Sponsor:
Jianfeng Xie
Conditions:
Sepsis
Eligibility:
All Genders
18-80 years
Brief Summary
Sepsis is a life-threatening disease characterized by multi-organ failure due to dysregulated host response to infection, with high global mortality of 30-50%. One of the most important pathophysiolog...
Detailed Description
We measured the levels of pyroptosis in patients admitted to the Department of Critical Care Medicine for sepsis and investigated the correlation with related markers of endothelium injury. Furthermor...
Eligibility Criteria
Inclusion
- Suspected or confirmed infection
- The sequential organ failure score (SOFA score) increases by more than or equal to 2 points on the basis
- Sign the informed consent
Exclusion
- the age \< 18 or \> 80 years of age
- pregnant
- tumor
- viral hepatitis or liver cirrhosis
- chronic renal tubular nephritis, chronic renal insufficiency
- ulcerative colitis or crohn's disease
- active systemic lupus erythematosus (SLE)
- acute myocardial infarction
- acute pancreatitis
- engaged in other clinical subjects
Key Trial Info
Start Date :
May 22 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04427371
Start Date
May 22 2020
End Date
December 31 2023
Last Update
June 11 2020
Active Locations (1)
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1
Zhongda Hospital, School of Medicine, Southeast University
Nanjing, Jiangsu, China, 210009