Status:
TERMINATED
The Effects of Low Dose Ketamine on Cardiovascular Function
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Healthy
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
Low dose ketamine is used for pain management and for the treatment of anxiety and depression. Prior studies on low dose ketamine have noted short-term (minutes to hours) increases or decreases in blo...
Eligibility Criteria
Inclusion
- Non-obese (body mass index less than 30 kg/m2)
- \*alternatively, individuals will be permitted to participate if they have a body mass index value below 35 kg/m2 but a waist circumference below 88 cm for females and 102 cm for males
- Systolic blood pressure \<140 mmHg
- Diastolic blood pressure \<90 mmHg
Exclusion
- Participants who have cardiac, respiratory, neurological, and/or metabolic illnesses
- Current or previous use of anti-hypertensive medications
- Any known history of renal or hepatic insufficiency/disease
- Pregnancy or breast feeding
- Current smokers, as well as individuals who regularly smoked within the past 3 years
- Individuals with a history of drug abuse
- Individuals who have an unexplained positive urine drug screen (e.g., some agents cause false-positive results, but when the agent is abstained for hours/days/weeks, the repeated drug screen is negative. One example could be an over-the-counter supplement)
Key Trial Info
Start Date :
November 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 28 2021
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT04429685
Start Date
November 1 2020
End Date
May 28 2021
Last Update
May 21 2024
Active Locations (1)
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1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390