Status:
ACTIVE_NOT_RECRUITING
Dosimetry, Safety and Potential Benefit of 177Lu-PSMA-617 Prior to Prostatectomy
Lead Sponsor:
Peter MacCallum Cancer Centre, Australia
Collaborating Sponsors:
Movember Foundation
Medical Research Future Fund
Conditions:
Prostatic Neoplasms
Eligibility:
MALE
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This clinical trial will evaluate the dosimetry, efficacy and toxicity of Lu-PSMA in men with high PSMA-expressing high-risk localized or locoregional advanced prostate cancer (HRCaP) undergoing radic...
Detailed Description
This open label, phase I/II non-randomised clinical trial will evaluate the dosimetry, efficacy and toxicity of Lu-PSMA in men with high PSMA-expressing high-risk localized or locoregional advanced pr...
Eligibility Criteria
Inclusion
- Patient has provided written informed consent.
- Male patient aged 18 or over at the time of screening
- Histologically confirmed adenocarcinoma of the prostate, in a patient scheduled for RP and PLND with curative intent
- High or high-intermediate risk localised or locoregional prostate cancer (HRCaP) by European Association of Urology (EAU) criteria, including any of the following:
- PSA \> 20 ng/mL
- ISUP grade group 3-5
- Clinical T-stage by digital rectal examination (DRE) of T2c or higher
- N1 disease (involvement of lymph nodes at or below the bifurcation of the common iliac arteries)
- defined radiologically (CT/ MRI, or PSMA PET).
- High PSMA avidity on 68Ga-PSMA PET/CT, defined as an SUVmax of ≥ 20
- Normal baseline haematological function; haemoglobin 13.5-17.5g/dl), total white blood cell count (4-11 x 109/l), platelets (150-400 x 109/l), neutrophils (2-7.5 x 109/l) and lymphocytes (1-4 x 109/l)
- Normal baseline serum biochemistry; sodium 135-145 nmol/l, potassium 3.5-5 nmol/l, chloride 98-108 nmol/l, urea 3-9.2 nmol/l, creatinine 60-120μmol/l
- Willing and able to comply with all study requirements including all treatments and required assessments including follow up
Exclusion
- Prostate cancer with significant neuroendocrine or other rare variant pathology
- Prior treatment for prostate cancer including radiotherapy and/or androgen deprivation therapy.
- Evidence of metastatic disease involving bone, viscera, or lymph nodes superior to the common iliac bifurcation based on CT, MRI, WBBS or PSMA PET/CT.
- Renal impairment \[GFR \< 60mL/min\].
- Sjogren's syndrome.
- A history of or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the patient's participation for the full duration of the trial, or is not in the best interest of the patient to participate, in the opinion of the treating investigator.
Key Trial Info
Start Date :
August 6 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 30 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04430192
Start Date
August 6 2020
End Date
August 30 2025
Last Update
November 8 2024
Active Locations (1)
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1
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia, 3000