Status:
NOT_YET_RECRUITING
Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure)
Lead Sponsor:
Barts & The London NHS Trust
Collaborating Sponsors:
University College, London
Conditions:
Aortic Valve Disease
Surgery--Complications
Eligibility:
All Genders
18+ years
Brief Summary
There is considerable morbidity and mortality associated with cardiac surgery. Currently little effort is made to quantify how well the immune system of an individual can cope with inflammation or inf...
Detailed Description
Experimental design and methods: Setting: Barts Heart Centre is a 255-bedded specialist cardiac centre where approximately 200 primary isolated open aortic valve replacement procedures are performed...
Eligibility Criteria
Inclusion
- • Patients undergoing first-time open aortic valve replacement surgery
Exclusion
- Age less than 18y (capacity to consent)
- Ongoing sepsis (immunomodulatory effects, established influence on outcome from surgery)
- Immunosuppressive therapy
- Suffering from known immunosuppressive disease
- Pregnancy (immunosuppressive aspects to pregnancy)
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04430972
Start Date
September 1 2025
End Date
September 1 2026
Last Update
November 18 2024
Active Locations (1)
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1
St Bartholomew's Hospital
London, United Kingdom, EC1A 7BE