Status:
RECRUITING
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Familial Cancer
BRCA1-Associated Protein-1 (BAP1) Mutations
Eligibility:
All Genders
30+ years
Brief Summary
Background: A germline mutation is a change to a person s genes that is carried through their DNA. These mutations can be passed on from parents to their offspring. Germline mutations in a gene calle...
Detailed Description
Background: * Mutations involving BRCA1-Associated Protein-1 (BAP1), a nuclear deubiquitinase involved in epigenetic regulation of gene expression, DNA repair, and cellular energetics, have emerged a...
Eligibility Criteria
Inclusion
- ELIGIBILITY CRITERIA:
- Inclusion Criteria for Genetic Testing
- Eligible participants include:
- -Individuals with a history of any malignancy with known or suspected germline mutations involving BAP1
- OR
- -First- or second-degree relatives of patients (with or without cancer) with documented BAP1 tumor predisposition syndrome (TPDS).
- Age greater than or equal to 30 years.
- All participants must understand and be willing to sign a written informed consent document.
- Inclusion Criteria for Surveillance
- Eligible participants include those who completed step 1 genetic testing with study-confirmed BAP1 or other germline TPDS mutation.
- Completed co-enrollment on protocol 06C0014, "Prospective Evaluation of Genetic and Epigenetic Alterations in Patients with Thoracic Malignancies."
Exclusion
Key Trial Info
Start Date :
March 30 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2038
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT04431024
Start Date
March 30 2021
End Date
June 30 2038
Last Update
December 24 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892