Status:
NOT_YET_RECRUITING
Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty
Lead Sponsor:
Henry Ford Health System
Conditions:
Arthritis Knee
Postoperative Nausea
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This study aims to determine if oral dexamethasone provides clinically significant improvement in postoperative outcomes, specifically nausea and pain scores.
Detailed Description
Protocols in perioperative pain management during total joint arthroplasty (TJA) have contributed to early discharge after surgery. As practices move to favor ambulatory surgery in total joint arthrop...
Eligibility Criteria
Inclusion
- adult patients age 18 and older who will be undergoing joint replacement
Exclusion
- Patients with uncontrolled diabetes ( HbA1C, \>7.5%), impaired hepatic function (Child class, \>B), impaired renal failure (Glomerular filtration rate \<60 mL/min/1.73 m2), chronic narcotic use, alcohol and/or opioid dependence, patients with a known adverse reaction to corticosteroids, and patients unable to give informed consent.
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04432259
Start Date
July 1 2020
End Date
December 1 2022
Last Update
June 16 2020
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