Status:
COMPLETED
Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder
Lead Sponsor:
Rutgers University
Conditions:
Opioid-use Disorder
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The primary aims of this study are to identify impaired cognitive control in opioid use disorder (OUD) and subsequently to examine the effects of transcranial magnetic stimulation (TMS) on reward proc...
Detailed Description
The design is primarily a randomized control-trial design, comparing the effects of placebo (sham) and active TMS stimulation on reward processing across two groups of participants - healthy controls ...
Eligibility Criteria
Inclusion
- Native English speakers
- Males and Females aged 18-55 years old
- Ability to provide informed written or verbal consent
- Opioid dependent individuals (according to the Alcohol, Smoking and Substance Involvement Screening Test opioid dependence score), or
- Healthy controls with no history of significant substance use
Exclusion
- Un-correctable visual impairment
- Uninterruptable central nervous system medication
- TMS contraindications (e.g., pregnancy, braces, history of seizures, metal implants).
- History of neurological or psychiatric illness
- Diagnosed learning disability
- History of significant head injury (loss of consciousness for more than five minutes)
- Substance abuse (Participants who score above 39.5 on the Global Continuum of Substance Risk scale of the Alcohol, Smoking and Substance Involvement Screening Test - controls only)
- Use of psychoactive or vasoactive medications
Key Trial Info
Start Date :
February 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2022
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT04432493
Start Date
February 20 2020
End Date
August 31 2022
Last Update
March 8 2024
Active Locations (1)
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1
Rutgers University - Newark
Newark, New Jersey, United States, 07102