Status:
COMPLETED
Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Vinmec Research Institute of Stem Cell and Gene Technology
Conditions:
COPD
Eligibility:
All Genders
40-75 years
Phase:
PHASE1
PHASE2
Brief Summary
This trial is to investigate the safety and potential therapeutic efficacy of allogeneic administration of umbilical cord-derived MSCs (UC-MSCs) as a supplementary intervention in combination with sta...
Detailed Description
The aim of this trial is to investigate the safety and potential therapeutic efficacy of allogeneic administration of umbilical cord-derived MSCs (UC-MSCs) as a supplementary intervention in combinati...
Eligibility Criteria
Inclusion
- Diagnosed with COPD with stage B, C, or D according to GOLD 2019.
- Age between 40-75 years old.
- Both genders.
Exclusion
- Smoker or less than 6 months of smoking cessation time.
- Asthma and other pulmonary-related diseases and injuries (including lung tuberculosis, restrictive lung disease, idiopathic pulmonary fibrosis, or lung cancer).
- Acute and/or active infection.
- Cancer.
- Patients with complex cardiovascular diseases (including valvular heart disease, cardiomyopathy, arrhythmia, congenital heart disease, hypertrophy syndrome).
- Liver and kidney failure.
- Pregnancy.
- Patients with life expectancy less than 6 months due to concomitant illness.
- Under immunosuppressive treatment within 8 weeks of the first screening visit.
- Patient diagnosed diabetes with HbA1C\>7%
Key Trial Info
Start Date :
June 9 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 25 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04433104
Start Date
June 9 2020
End Date
December 25 2022
Last Update
June 4 2024
Active Locations (1)
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1
Vinmec International Hospital Times City
Hanoi, Hanoi, Vietnam, 100000