Status:
UNKNOWN
Ivermectin vs Combined Hydroxychloroquine and Antiretroviral Drugs (ART) Among Asymptomatic COVID-19 Infection
Lead Sponsor:
Mahidol University
Conditions:
Asymptomatic Infections
SARS-CoV2 Infection
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This is an open label randomised controlled study of oral ivermectin (600 mcg/kg/d\* 3 day) versus combined of hydroxychloroquine plus darunavir/ ritonavir for 5 days treatment among asymptomatic carr...
Detailed Description
* Study procedure will be carried out after informed consent is obtained. * Baseline physical exam and laboratory investigations will be performed. * Eligible patients will be randomized to one of the...
Eligibility Criteria
Inclusion
- SAR-CoV2 detected by PCR from NP swab
- Asymptomatic or upper respiratory symptoms such as runny noses
- No history of fever or oral Temp \<37.8 degree celsius
- informed consent obtained
Exclusion
- Fever or respiratory rate \>24/minute or oxygen saturation at room air\< 94%
- Any serious co-morbidity such as chronic lung disease, chronic kidney disease, cardiovascular diseases, arrythmia, diabetes mellitus with HbA1C \> 8%, chronic liver disease, lymphocyte count \<1,000cell/cu.mm.
- History of ivermectin or any of the study drug allergy.
- Concomitant medication with potential drug interaction with any of the study drugs such as alfuzosin, colchicine, ergot derivatives, cisapride, simvastatin and rifampicin
- Pregnant or lactating woman
Key Trial Info
Start Date :
July 13 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2021
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04435587
Start Date
July 13 2020
End Date
November 1 2021
Last Update
January 11 2021
Active Locations (4)
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1
Siriraj Hospital
Bangkok Noi, Bangkok, Thailand, 10700
2
Siriaj Hospital
Bangkok, N/A = Not Applicable, Thailand, 10700
3
Sireethorn Nimitvilai
Amphoe Maueng, Nakhonpathom, Thailand, 73000
4
Golden Jubilee Medical Center
Phutthamonthon District, Nakhonpathom, Thailand, 73170