Status:
COMPLETED
Clinical and Physiological Assessment of a Nearly Ultra-protective Lung Ventilation Strategy: A Quasi-experimental Preliminary Study in ARDS Patients
Lead Sponsor:
Clinica las Condes, Chile
Conditions:
ARDS
Volumetric Capnography
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to determine whether a protective mechanical ventilator strategy generates a reduction in the Bohr´s dead space in patients with moderate or severe acute respiratory distress syndrome ...
Detailed Description
Protective mechanical ventilation strategies are currently the cornerstone of treatment for patients undergoing mechanical ventilatory support. Among them, we can mention the reduction in tidal volume...
Eligibility Criteria
Inclusion
- Age older than 18 years
- The requirement of invasive mechanical ventilation for more than 4 hours and less than 72 hours
- Severe hypoxemia (PAFI \< 200) secondary to ARDS
Exclusion
- Heart failure stage IV
- Chronic obstructive pulmonary disease (COPD) on home oxygen
- Bronchopulmonary fistula
- Hypovolemic Shock with active hemorrhage
- Gastrointestinal bleeding
- Oesophageal Varices
- Nasopharynx surgery, recent oesophageal or gastric surgery
- Massive Pulmonary Thromboembolism
- Catastrophic respiratory failure requiring urgent extracorporeal life support
- Respiratory acidosis. Hydrogen potential (pH) is less than 7.20 and PaCO2 higher than 60 mmHg at baseline.
Key Trial Info
Start Date :
September 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2020
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04435613
Start Date
September 4 2019
End Date
August 30 2020
Last Update
October 8 2021
Active Locations (1)
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1
Clínica Las Condes
Santiago, Santiago Metropolitan, Chile, 13114