Status:
COMPLETED
Hydrocortisone Per-treatment Decrease Side Effects of Protamine Sulfate
Lead Sponsor:
University of Jordan
Conditions:
Blood Pressure
Heart Rate
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
This study aims to compare the hemodynamic parameters within and between patients who received Protamine Sulfate (PS) with Hydrocortisone (HC) vs. Protamine Sulfate alone during cardiac surgeries.
Detailed Description
the investigators hypothesized that patients received PS along with HC would have different results in intraoperative hemodynamic changes of the blood pressure - both Systolic Blood Pressure (SBP), Di...
Eligibility Criteria
Inclusion
- Patients who had cardiac surgery using cardiopulmonary bypass
- Normal preoperative hemoglobin level
- Normal preoperative platelet count
- No known defect of the coagulation system
- Patients with unimpaired renal function (creatinine clearance \< 30 ml/kg/min)
Exclusion
- Patients younger than 18 years
- Patients with known defect of the coagulation system
- Renal impairment
- Previous vasectomy
- Allergy to fish
- Unable to give consent form
Key Trial Info
Start Date :
July 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2020
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04435912
Start Date
July 4 2019
End Date
June 1 2020
Last Update
June 17 2020
Active Locations (1)
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1
Faculty of Medicine
Zarqa, Jordan, 13133