Status:
COMPLETED
Trial of Antimicrobial Restraint in Presumed Pneumonia
Lead Sponsor:
University of Kansas Medical Center
Collaborating Sponsors:
Western Michigan University
Conditions:
Healthcare-Associated Pneumonia
Sepsis
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
The objective of this cluster-randomized crossover study is to determine the effect of delaying antimicrobial initiation until objective microbiologic data is obtained in patients with presumed ICU-ac...
Detailed Description
This study will involve 8 centers is to determine the effect of delaying antimicrobial initiation until objective microbiologic data is obtained in patients with presumed ICU-acquired pneumonia withou...
Eligibility Criteria
Inclusion
- Intubated patients admitted to a surgical or trauma intensive care unit that have had an appropriate quantitative or semi-quantitative endobronchial sputum culture sent ≥48 hours into their ICU admission
- Primary pathology managed by surgical specialty
- Age ≥18 years.
Exclusion
- Non-intubated patients.
- Intubated patients with concern for active infection that is not suspected to be pneumonia (i.e. intra-abdominal infection, skin and soft tissue infection, urinary tract infection, etc.)
- Primary disease not surgical or traumatic in nature
- Primary diagnosis of burns
- Incarcerated status
- Pregnant status or delivery during this hospitalization.
- On active immunosuppressive medications (or taking as a home medication prior to arrival)
Key Trial Info
Start Date :
February 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2022
Estimated Enrollment :
186 Patients enrolled
Trial Details
Trial ID
NCT04438187
Start Date
February 1 2021
End Date
June 30 2022
Last Update
August 19 2024
Active Locations (1)
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1
KU Medical Center
Kansas City, Kansas, United States, 66160