Status:
COMPLETED
The Immunological Profile of Nickel Dermatitis
Lead Sponsor:
National Allergy Research Center, Denmark
Collaborating Sponsors:
University of Copenhagen
Conditions:
Nickel; Eczema
Nickel Sensitivity
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
A dose-response study on the immune phenotype of allergic nickel dermatitis on a previously exposed skin area.
Detailed Description
Clinically controlled study comprising 15 people with known nickel allergy and 15 healthy persons as control group. At the Department of Allergy and Dermatology, Gentofte Hospital, test participants w...
Eligibility Criteria
Inclusion
- inclusion criteria
- Must be able to understand the written and oral participant information in Danish.
- Previously proven nick allergy by patch testing within the last 5 years, for the nickel allergic test participants.
- exclusion criteria
- Pregnancy and / or breastfeeding.
- Systemic immunomodulatory treatments within the last 14 days.
- Local treatments of selected skin areas, such as applying hormone cream within the last two weeks or applying cream / lotion within 24 hours up to sample collection.
- Allergy to local anesthesia.
- Exposed to solar or sunlight on the back within 21 days.
- History of inflammatory skin diseases, asthma, Diabetes Mellitus, hives or arthritis (exclusion criteria only for participation in the healthy control group).
- Participation in another scientific experiment within the last 4 weeks. risks,
Exclusion
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2022
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04438330
Start Date
March 1 2021
End Date
June 1 2022
Last Update
January 4 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Allergy Research Center
Hellerup, Danmark, Denmark, 2900