Status:
RECRUITING
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
Lead Sponsor:
University of Minnesota
Conditions:
Hypertension
Menopause, Premature
Eligibility:
FEMALE
35-70 years
Brief Summary
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) ...
Detailed Description
Aim One: Determine mechanisms driving autonomic dysregulation of blood pressure (BP) in premature and early menopausal women. Because sympathetic activity and baroreflex function are important contrib...
Eligibility Criteria
Inclusion
- Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause
- Premenopausal 35-49 years of age
- Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
- Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \>30 mIU/mL
Exclusion
- Current nicotine/tobacco use within the past six months
- Are diabetic or asthmatic
- Have diagnosed significant carotid stenosis
- Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.
- Have existing metabolic or endocrine abnormities
- Take any heart/blood pressure medications that are determined to interfere with study outcomes
- IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes
- Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study
- Are pregnant or breastfeeding
Key Trial Info
Start Date :
October 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04439370
Start Date
October 1 2019
End Date
December 30 2026
Last Update
January 8 2026
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455