Status:
UNKNOWN
Evaluation of Immunoprotection Provided by Hepatitis B Vaccine After Birth in Healthy Children
Lead Sponsor:
Children's Hospital of Chongqing Medical University
Conditions:
Vaccine Reaction
Eligibility:
All Genders
1-15 years
Brief Summary
Worldwide, hepatitis B virus (HBV) infection is a major cause of acute hepatitis,and chronic infection with HBV often leads to chronic hepatitis, liver cirrhosis,and hepatocellular carcinoma. So far, ...
Detailed Description
One method to determine the long-term protection provided by hepatitis B vaccine against HBV infection is to estimate the cumulative incidence of chronic carrier status and breakthrough infection of p...
Eligibility Criteria
Inclusion
- Children who are 1-15 years old in Chongqing
- After birth, three injections of Hep B were inoculated in time according to the procedure of 0, 1 and 6 months(The vaccination certificate record)
- No HBV booster vaccine given since primary HBV immunization
- Children or guardian knew and agreed to accept the study
- Follow - up study and blood collection after vaccination can be accepted
Exclusion
- Unwilling or impossible to participate in this research project;
- Have a history of allergy or have had a serious vaccine reaction
- Have immune impairment diseases and appear immune impairment;
- Immunosuppressive treatment, receive any injection or oral administration of cortisone or cancer chemotherapy;
- Any kind of vaccine or any kind of observation drug has been vaccinated in the past four weeks;
- Any acute disease or other infection requiring antibiotic or antiviral treatment in the past four weeks;
- Fever symptoms occurred in the past week ( axillary temperature ≥ 38 °C)
- Blood transfusion experience;
- Has a history of more serious infectious diseases ( five types of hepatitis, AIDS, syphilis, gonorrhea, etc. );
- Hepatitis B infection or carriers(lineal relationship);
- Abnormal physical examination
Key Trial Info
Start Date :
July 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04439435
Start Date
July 1 2020
End Date
October 1 2021
Last Update
June 19 2020
Active Locations (1)
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1
Chongqing Children's Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China