Status:
COMPLETED
CRPS - Diagnostics, Pathophysiological Mechanisms, and Response to Treatment With Noninvasive Brain Stimulation
Lead Sponsor:
Helsinki University Central Hospital
Collaborating Sponsors:
Turku University Hospital
Conditions:
Transcranial Magnetic Stimulation
Complex Regional Pain Syndrome of Upper Limb (Disorder)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a sham controlled, randomized, double-blind, navigated repetitive Transcranial Magnetic Stimulation (nrTMS) study for the treatment of complex regional pain syndrome (CRPS types 1 and 2). The ...
Detailed Description
rTMS hypothetically disrupts the default networks related to chronic pain and renders the brain more susceptible to drugs, rehabilitation, or cognitive behavioral therapy. In addition, there is experi...
Eligibility Criteria
Inclusion
- CRPS 1 or 2 of the upper limb
- Duration ≥ 6 months
- Mean pain (NRS) intensity ≥5/10
- Medical and other therapies have failed
Exclusion
- Other stimulation therapies apart from transcutaneous nerve stimulation
- psychotic disorder
- severe depression
- use of strong opioids
- epilepsy
- any contraindication for MRI
- abuse of alcohol or drugs
- ongoing insurance or other entitlement cases
Key Trial Info
Start Date :
August 28 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 25 2022
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT04439669
Start Date
August 28 2017
End Date
August 25 2022
Last Update
July 3 2024
Active Locations (2)
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1
Turku University Hospital, Pain Clinic
Turku, Southwest Finland, Finland, 20014
2
Helsinki University Hospital, Pain Clinic
Helsinki, Uusimaa, Finland, 00029