Status:
RECRUITING
Mechanisms and Modulation of Pain Modulatory Capacity
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Musculoskeletal Pain
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This project proposes to understand the sources of pain variability, and demonstrate that pain variability represents fluctuation in natural pain management. The project further proposes to determine ...
Detailed Description
Many physiological systems (bioenergy, immune etc.) involve feedback mechanisms to respond to challenges, with increased output or capacity for adaptive change. A similar process is plausible for pain...
Eligibility Criteria
Inclusion
- Asymptomatic people (ie no current pain conditions)
- Participants with widespread muscle pain (WMP) aged 18 years of age and older
- Participants with WMP must meet the ACR (2010) diagnostic criteria of multiple regions of muscle pain
- The asymptomatic group will be free of current wrist/hand, elbow, or shoulder pain and chronic pain conditions (eg irritable bowel syndrome, FM)
Exclusion
- Participation in a conditioning program specific to the biceps in the past 6 months
- Any report of wrist/hand, elbow, or shoulder pain in the last 3 months
- Any chronic medical conditions that may affect pain perception (e.g., diabetes, high blood pressure), kidney dysfunction, muscle damage, or major psychiatric disorder
- Use of any intervention (including but not limited to medication, massage, and stretching) for symptoms induced by pain training for the duration of the study
- Positive result on pre-MRI metal screening or pregnancy test due to contraindication for the MRI environment.
- Any participant with ferromagnetic metal in the head, neck, or abdominal cavity
Key Trial Info
Start Date :
November 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT04441619
Start Date
November 30 2020
End Date
April 30 2026
Last Update
May 21 2025
Active Locations (1)
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1
Unversity of Florida
Gainesville, Florida, United States, 32611