Status:
RECRUITING
Mechanisms of Fatigability With Diabetes
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
University of Illinois at Chicago
Medical College of Wisconsin
Conditions:
Pre-diabetes
Type 2 Diabetes
Eligibility:
All Genders
30-85 years
Phase:
NA
Brief Summary
Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance. The cause for the increas...
Detailed Description
The aim of the clinical trial is to determine the effectiveness of dynamic resistance exercise training coupled with blood flow restriction to improve fatigability and vascular function in people with...
Eligibility Criteria
Inclusion
- Men and women adults 30 years to 85 years or less
- Pre-diabetes \[glycosylated hemoglobin (HbA1c) of 5.7-6.4% and fasting plasma glucose 100-125 mg/dL at the time of initial screening\]
- Controls \[normoglycemic with a HbA1c level ≤5.6% and fasting blood glucose ≤ 99 mg/dL (5.5 mmol/L)\]
- Type 2 Diabetes Mellitus \[elevated glycosylated hemoglobin (HbA1c) \>6.5% and \<10%\]
Exclusion
- Signs or symptoms of neuropathy
- Medications associated with advanced stages of T2D including insulin
- Poor glycemic control (HbA1c\>10%)
- Peripheral edema
- Severe obesity (BMI, \>45kg·m-2)
- Untreated hypothyroidism
- Smoking
- Hypertension
- Cardiovascular or musculoskeletal disease that preclude exercise testing
- Hormone replacement drugs or vasoactive medications
Key Trial Info
Start Date :
September 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04442451
Start Date
September 1 2022
End Date
August 31 2027
Last Update
October 8 2025
Active Locations (1)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48109