Status:
UNKNOWN
Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy
Lead Sponsor:
Peking University Third Hospital
Conditions:
Radiation Therapy
Eligibility:
All Genders
Brief Summary
The purpose of this study is to detecte and predict early subclinical cardiac damage induced by thoracic radiation therapy based on two-dimensional speckle tracking echocardiography combined with mult...
Detailed Description
This is a monocentric prospective cohort study in which 100 patients treated for malignant tumors and with cardiac radiation exposure will be included.All patient will be followed for 12 months after ...
Eligibility Criteria
Inclusion
- with malignant tumors
- will receive radiotherapy
- with cardiac exposure during the radiotherapy process
- could receive regular follow-up for 12 months
- written informed consent
Exclusion
- satisfactory echocardiographic images could not be obtained
- moderate or severe valvular disease
- cardiomyopathy
- congenital heart disease
- refractory hypertension
- coronary artery disease\*
- heart failure
- arrhythmia requiring intervention
- pericarditis
- acute myocarditis
- participating in other clinical studies of drug intervention
- severe liver and kidney dysfunction
- autoimmune disease
- pulmonary hypertension
- coronary artery disease: at least 50% stenosis besed on previous coronary angiography or CTA, or with a history of percutaneous coronary stent implantation.
- \*: with LVEF\<50%, unstable angina，or acute myocardial infarction within 3 months.
Key Trial Info
Start Date :
January 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04443400
Start Date
January 1 2020
End Date
December 31 2021
Last Update
June 23 2020
Active Locations (1)
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1
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191