Status:
COMPLETED
Molecular Pathways Involved in Knee Pain
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
Versus Arthritis
Conditions:
Knee Osteoarthritis
Knee Pain Chronic
Eligibility:
All Genders
45+ years
Brief Summary
Knee osteoarthritis (OA) is the most common form of arthritis and the most common cause of knee pain in the world. The rate of knee arthritis is as high as that of cardiac disease and is the most comm...
Detailed Description
Osteoarthritis (OA) is the most common cause of disability in the elderly population and most individuals suffering from osteoarthritis are managed in the primary care setting. Knee OA is the most com...
Eligibility Criteria
Inclusion
- have the ability to give informed consent
- be 45 years or over
- have complaints of knee pain for 3-6 months with or without radiographically established OA (K/L scale score ≥ 1)
- have complaints of knee pain for 3-6 months with or without satisfying the non-radiographic American College of Rheumatology criteria for knee OA
- are willing to undertake knee synovial fluid aspiration
- be able to speak, read, and write in English as all instructions and questionnaires are designed in the English language
Exclusion
- Inability to give informed consent due to cognitive impairment or otherwise - (capacity levels are already established under General Practitioner care)
- Inability to understand key aspects of the study due to cognitive impairment or otherwise
- Giving history of additional co-morbidities such as cancer, neurological conditions, inflammatory joint diseases including rheumatoid arthritis, diabetic neuropathies, fractures or other conditions causing greater disability than their knee pain
- Acute soft tissue injury to the knee within last 3 months before potential recruitment
Key Trial Info
Start Date :
November 6 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2023
Estimated Enrollment :
71 Patients enrolled
Trial Details
Trial ID
NCT04443452
Start Date
November 6 2020
End Date
December 1 2023
Last Update
August 13 2025
Active Locations (1)
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1
The University of Nottingham, City Hospital Campus
Nottingham, Nottinghamshire, United Kingdom, NG5 1PB