Status:
UNKNOWN
Cerebral Small Vessel Disease and Perioperative Covert Stroke
Lead Sponsor:
RenJi Hospital
Conditions:
Cerebral Small Vessel Diseases
Covert Postoperative Stroke
Eligibility:
All Genders
65-85 years
Brief Summary
MOCSS study is a multicenter prospective clinical cohort study. The purpose of the MOCSS study is to investigate whether there is a correlation between the preoperative cerebral small vessel disease a...
Detailed Description
With the growing number of the older population, surgery for elderly patients is on the rise. Elderly patients often have more cardiovascular disease and brain vulnerability and tend to experience mor...
Eligibility Criteria
Inclusion
- Age from 65 years to 85 years;
- The patient is about to have major surgery for the first time and the operation is non-cardiac surgery;
- Written informed consent is obtained before the surgery.
Exclusion
- mental illness;
- Already have other diseases that can cause dementia, such as Alzheimer's disease, Lewy body dementia, Frontotemporal dementia, progressive supranuclear palsy, Parkinson's disease, Creutzfeldt-Jakob disease, Huntington's disease, alcohol and drug dependence, Neurosyphilis, systemic lupus erythematosus; or preoperative MRI shows hippocampal and temporal lobe atrophy more than two levels, suggesting the possibility of Alzheimer's disease
- Have suffered from other brain diseases (such as stroke, multiple sclerosis, central nervous system infection with sequelae, etc.);
- Preoperative MRI indicates covert stroke
- MMSE or MoCA scale cannot be completed due to other reasons (such as hearing impairment or visual impairment)
- MRI contraindications before or after surgery or patients who cannot tolerate MRI imaging
- Stage 3 or 4 malignant tumors, and high malignancy and poor prognosis cancer, such as pancreatic cancer, gallbladder cancer, and bile duct cancer.
Key Trial Info
Start Date :
August 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
548 Patients enrolled
Trial Details
Trial ID
NCT04443933
Start Date
August 1 2020
End Date
December 1 2023
Last Update
June 22 2023
Active Locations (1)
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1
Renji Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China