Status:
COMPLETED
Short Term Corticosteroids in SARS-CoV2 Patients
Lead Sponsor:
The Miriam Hospital
Conditions:
Corticosteroids
Covid19
Eligibility:
All Genders
18+ years
Brief Summary
The investigators reviewed the charts of SARS-CoV-2 patients with pneumonia and moderate to severely elevated CRP and worsening hypoxemia who were treated with early, short-term dexamethasone.
Eligibility Criteria
Inclusion
- Moderate disease with at least a 30% increase in CRP within 36 hours of admission, and with increasing oxygen requirements.
- All patients with severe disease with evidence of escalating oxygen requirements
- The presence of secondary bacterial infections as a probable cause of increasing CRP levels was excluded in all selected patients.
- Pulmonary embolism and /or cardiac dysfunction were excluded as probable causes of worsening hypoxia in all selected patients.
Exclusion
- All patients on other treatment modalities- Remdesivir and/or Convalescent plasma who showed evidence of clinical improvement as per decrease in CRP levels and/or oxygen requirements were excluded.
- Patient with associated COPD exacerbation who would benefit from the use of steroids.
- Patients with Diabetic ketoacidosis, hyperglycemic hyperosmolar state, active concurrent bacterial infections.
- Patients with history of steroid-induced mania and/or psychosis.
Key Trial Info
Start Date :
April 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 31 2020
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04445506
Start Date
April 1 2020
End Date
May 31 2020
Last Update
June 24 2020
Active Locations (1)
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1
The Miriam Hospital
Providence, Rhode Island, United States, 02906