Status:
COMPLETED
Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure
Lead Sponsor:
I.M. Sechenov First Moscow State Medical University
Conditions:
SARS Pneumonia
Eligibility:
All Genders
18-90 years
Brief Summary
Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selec...
Detailed Description
In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. The World Health Organization (WHO) declared the outbreak a pandemic on March 11...
Eligibility Criteria
Inclusion
- all patients with COVID-19 and acute respiratory failure on invasive and noninvasive ventilation
Exclusion
- Patients who reached the following goals at conventional oxygen therapy (oxygen flow \< 15 l/min): peripheral capillary oxygen saturation(SpO2) \> 93%, no visible work of auxiliary respiratory muscles, no fatigue, stable hemodynamics (no need in any catecholamines and/or life-threatening heart rhythm abnormalities),
- less than 24 ours in intensive care unit (ICU) by any reason,
- lung emphysema,
- primary lung diseases (chronic obstructive lung disease-COPD, interstitial lung diseases, etc) or tumour metastases in lungs,
- chronic decompensated diseases with extrapulmonary organ dysfunction (tumour progression, liver cirrhosis, congestive heart failure),
- atonic coma.
Key Trial Info
Start Date :
May 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 14 2020
Estimated Enrollment :
117 Patients enrolled
Trial Details
Trial ID
NCT04445961
Start Date
May 1 2020
End Date
August 14 2020
Last Update
August 27 2020
Active Locations (3)
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1
Sechenov University Clinic #1
Moscow, Russia
2
Sechenov University Clinic #3
Moscow, Russia
3
Sechenov University Clinic #4
Moscow, Russia