Status:
RECRUITING
VACcination of LIver Transplantation Candidates
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Liver Transplant; Complications
Vaccination; Complications
Eligibility:
All Genders
18+ years
Brief Summary
Chronic hepatic disease, and especially cirrhosis, are associated to a global dysfunction of the immune system. Liver transplantation represents the only replacement therapy for end-stage liver diseas...
Eligibility Criteria
Inclusion
- age ≥ 18 years old
- patients waiting for liver transplantation referred by hepato-gastroenterology department as part of the pre-transplant evaluation to the infectiology consultation
- patient who were informed of the study and did not object to participate
Exclusion
- patient candidate for multi-organ transplant
- patient who received immunosuppressive therapy, biotherapy and/ or corticosteroid therapy at a dose greater than 10 mg / day of prednisone equivalent for more than 2 weeks within 3 months before vaccination (6 months of rituximab)
- patient who received polyvalent immunoglobulins within the 6 months before the serological evaluation
- patient who received systemic anti-cancer chemotherapy for solid tumor or hemopathy within 6 months preceding the start of vaccination
- splenectomized patients
- asplenic patients for a reason other than liver disease
- chronic infection with the human immunodeficiency virus (HIV)
- patient with any other hereditary immune deficiency or acquired which could compromise the vaccine response or interpretation of serological results
- patient under legal protection measure or unable to consent to the study
Key Trial Info
Start Date :
July 6 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 6 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04446832
Start Date
July 6 2020
End Date
July 6 2027
Last Update
November 9 2023
Active Locations (1)
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1
Service des maladies infectieuses et tropicales - Hôpital de la Croix-Rousse
Lyon, France, 69317