Status:
UNKNOWN
Influence of Local Anesthetic Administration on the Cancer Recurrence Rate After Pancreatic Oncologic Surgery
Lead Sponsor:
Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Conditions:
Pancreatic Cancer
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
Study aims to compare the influence of intravenous lidocaine and peridural ropivacaine on postoperative long and short term outcome in patients with pancreatic cancer undergoing surgery. As short ter...
Eligibility Criteria
Inclusion
- diagnosis of pancreatic cancer
- American Society of Anesthesiologists (ASA) risk I - III
Exclusion
- chronic pain
- chronic medication that may interfere with pain: antiepileptics, NSAID, corticoids
- contraindications for any of the study medications
- significant psychiatric disorders (major depression, bipolar disorders, schizophrenia, etc.)
- Convulsive disorders requiring medication during the last 2 years
- liver cirrhosis/chronic kidney disease stage IV or V/chronic heart failure class III or IV/ decompensated diabetes
- Corticoid dependent asthma
- Autoimmune disorders
- Anti-arrhythmic medication (verapamil, propafenone, amiodarone) that may interfere with lidocaine's anti-arrhythmic effects
- Refusal for study participation
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04449289
Start Date
July 1 2020
End Date
December 31 2024
Last Update
June 26 2020
Active Locations (1)
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1
Regional Institute of Gastroenterology and Hepatology "Prof. Dr. O. Fodor"
Cluj-Napoca, Romania