Status:
UNKNOWN
Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock
Lead Sponsor:
Zhongnan Hospital
Conditions:
Septic Shock
Fluid Resuscitation
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
In this prospective randomized controlled trial, investigators aim to study the effects and safety of bicarbonated Ringer's solution in patients with septic shock compared with lactated ringer's solut...
Detailed Description
Although the latest guidelines recommend crystalloids as the first choice for the patients' fluid resuscitation, it still remains controversial that which crystalloid solution is the best choice. It i...
Eligibility Criteria
Inclusion
- 1\. At the age of 18 to 75;
- 2\. Being treated in the ICU;
- 3\. Diagnosed as septic shock according tho the definition of Sepsis 3.0 with fluid resuscitation requirement.
Exclusion
- 1\. Severe hepatic failure;
- 2\. Possible brain injury;
- 3\. With absolute contraindications for central vena catheterization;
- 4\. Ever participated in another clinical trial within 30 days prior enrollment;
- 5\. Have corrected metabolic acidosis through alkaline drug application within 24 hours prior to enrollment;
- 6\. Hypermagnesemia or hypothyroidism;
- 7\. Pregnant of breast-feeding women;
- 8\. Considered inevitable death;
- 9\. Other situations where investigators think enrollment is not appropriate.
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 30 2021
Estimated Enrollment :
260 Patients enrolled
Trial Details
Trial ID
NCT04449757
Start Date
July 1 2020
End Date
May 30 2021
Last Update
June 29 2020
Active Locations (1)
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1
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China, 430000