Status:
UNKNOWN
Effects of Endothelin Receptor Antagonist on Ischemic Kidney Injury During Nephron Sparing Surgery
Lead Sponsor:
Bnai Zion Medical Center
Collaborating Sponsors:
Rambam Health Care Campus
Conditions:
Kidney Failure, Acute
Eligibility:
All Genders
18-99 years
Phase:
PHASE2
Brief Summary
Based on animal studies, it was found that administration of endothelial receptor antagonists before and after renal blood vessels clamp and release results in a significantly reduced renal function i...
Detailed Description
This is a study aimed at examining the protective effect of endothelin antagonism on the ischemic damage the kidney undergoes during partial nephrectomy for kidney lesion removal. In such procedure, ...
Eligibility Criteria
Inclusion
- Patients with a single kidney lesion who undergo Contrast enhancement (by CT scan)
- Normal contra-lateral kidney as illustrated by imaging tests
- Patients eligible for anesthesia and surgery
Exclusion
- Patients with chronic kidney infections
- Blood clot disorders
- End-stage renal failure
- Patients sensitive to the study drug
- Patients with cardiac heart failure, EF \<40%
- Patients with hyperkalemia
- Patients with systolic blood pressure under 90 mmHg
Key Trial Info
Start Date :
October 11 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04450095
Start Date
October 11 2018
End Date
October 1 2020
Last Update
June 29 2020
Active Locations (2)
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1
Bnai-Zion Medical Center
Haifa, Israel, 3339419
2
Department of Physiology, The Bruce and Ruth Rapapport Faculty of Medicine, Technion
Haifa, Israel, 3525408