Status:
COMPLETED
Role of NLRP3 in Periodontitis and Diabetes
Lead Sponsor:
University of Messina
Conditions:
Metabolic Disease
Periodontal Diseases
Eligibility:
All Genders
35-70 years
Brief Summary
NLRP3 plays a key role in endothelial function and may be a link for the known interaction of periodontitis and diabetes. The investigators compared the impact of gingival health, periodontitis (CP), ...
Detailed Description
The aim of this study was to evaluate a possible association between NLRP3 and gingival health, periodontitis (CP), diabetes or of both diseases (CP +diabetes) on saliva and serum NLRP3 levels.
Eligibility Criteria
Inclusion
- Presence of at least 15 teeth
- CP with a minimum of 40% of sites with a clinical attachment level (CAL)
- ≥2mm and probing depth (PD) ≥4mm;
- Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion
- Intake of contraceptives
- Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- Status of pregnancy or lactation
- Previous history of excessive drinking
- Allergy to local anaesthetic
- Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
Key Trial Info
Start Date :
June 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 30 2017
Estimated Enrollment :
133 Patients enrolled
Trial Details
Trial ID
NCT04450810
Start Date
June 1 2014
End Date
September 30 2017
Last Update
January 26 2021
Active Locations (1)
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1
University of Messina
Messina, Italy, 98100