Status:
COMPLETED
Probiotics-prebiotic Fiber Therapy in Parkinson's Disease Patients With Constipation
Lead Sponsor:
National University of Malaysia
Conditions:
Parkinson Disease
Constipation
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
A double blinded randomised placebo controlled trial to evaluate the efficacy of probiotics on constipation symptoms and whole gut transit time in patients with Parkinson's disease.PD patients with co...
Detailed Description
This was an eight-week double-blind, randomized placebo-controlled intervention study involving 55 idiopathic PD patients attending tertiary hospital. This study was conducted in accordance with good ...
Eligibility Criteria
Inclusion
- Age 18 or older; were diagnosed with idiopathic PD
- PD with Hoehn and Yahr stages 1-4,
- Fulfilled the Rome III criteria for functional constipation
Exclusion
- MMSE score of ≤ 21/30
- Positive stool occult blood screening
- Diagnosis of secondary parkinsonism
- Previous history of small and large bowel disease
- History of gastrointestinal tract surgery
- Use of probiotics or antibiotics two weeks prior to baseline visit
- Been on medications such as antidepressants or anticholinergics
- History of lactose intolerance
- Concomitant diagnosis of hypothyroidism and diabetes mellitus.
Key Trial Info
Start Date :
October 6 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 28 2019
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04451096
Start Date
October 6 2018
End Date
February 28 2019
Last Update
June 30 2020
Active Locations (1)
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1
Hospital Canselor Tuanku Muhriz, UKM Medical Center
Kuala Lumpur, Malaysia, 56000